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MCA was first synthesized in 1859 by the German chemist Johann Friedrich August Götte. It is produced industrially via the haloform reaction, where chloroform reacts with sodium hydroxide. Trichloroethylene is also used as a precursor in some production processes.
The worldwide demand for MCA has been steadily increasing over the years due to its multitude of uses. In 2020, the global MCA market was estimated to be worth over USD 750 million.
Major Uses
MCA finds extensive use as an important chemical intermediate in the production of several agrochemicals and pharmaceuticals. Some of its major applications include:
- Herbicides: It is used to synthesize many chloroacetanilide herbicides such as alachlor, butachlor and metolachlor. These are widely used to control broadleaf weeds and annual grasses.
- Pharmaceuticals: It acts as a starting material in the manufacture of several drugs like procaine, lignocaine and ibuprofen. It is also used as an antiseptic.
- Surfactants: MCA is a precursor for many surfactants and detergents. Sodium chloroacetate produced from it is used to make carboxmethylcellulose.
- Other uses: Other minor applications of MCA include in the production of dyes, resins, flavorings and in metal pickling. It is also used as a corrosion inhibitor and for derusting.
Health and Environmental Hazards
While MCA has proven economic benefits, it also poses certain health and environmental risks that warrant safety precautions. Major hazards associated with it include:
- Toxicity: MCA is highly toxic and can cause severe damage if swallowed, inhaled or absorbed through skin. It may even prove fatal at high doses. Prolonged exposure can damage liver and kidneys in humans.
- Corrosiveness: Due to its acidic nature, MCA can cause blistering of skin upon contact. It is severely corrosive to eyes as well.
- Groundwater contamination: Spills of MCA can readily contaminate soil and groundwater. As it does not readily degrade, it may persist in the environment for long.
- Environmental toxicity: MCA is toxic to aquatic organisms. It has been found to bioaccumulate in some fish species.
- Occupational hazard: Workers involved in its production and handling are at high risk of exposure through inhalation or skin contact. Strict safety protocols must be enforced.
Given these risks, MCA is designated as a hazardous substance and its production and use entail compliance with stringent safety and environmental regulations around the world.
Regulatory Standards
In view of the toxicity concerns around MCA, various regulatory agencies have established exposure limits and handling guidelines over the years. Some key global standards include:
- OSHA (USA): The occupational safety limit set by the Occupational Safety and Health Administration for an 8-hour exposure is 3 ppm. The short-term exposure limit is 6 ppm.
- NIOSH (USA): The National Institute for Occupational Safety and Health recommends that MCA exposure be limited to 3 ppm over a 15-minute period.
- ACGIH (International): The American Conference of Governmental Industrial Hygienists exposure limit is 3 ppm for an 8-hour workday.
- EU Standards: The European Union has classified MCA as hazardous and restricted its usage through strict REACH regulations on manufacture, placing on the market and use.
- Other countries: Several other countries like Canada, Australia, China, India etc. have also implemented exposure guidelines and pollution control norms for safe MCA production and handling.
Proper implementation of such regulatory standards helps protect workers and the environment from risk while also allowing its continued industrial usage. Safe manufacturing practices like enclosed systems, personal protective equipment for workers and pollution abatement measures form important compliance requirements.
To summarize, Monochloroacetic acid holds tremendous commercial importance as a platform chemical enabling many pharmaceuticals and agrochemicals that improve our lives. However, due to its inherent toxicity, utmost precautions must be adopted from production to disposal in order to prevent adverse health or environmental impacts. With stringent regulatory frameworks and adherence to safety protocols, the benefits of this indispensable industrial chemical can be availed sustainably.
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